Comments on: Solving puzzles of mitochondrial variation within and among species http://phe.rockefeller.edu/barcode/blog/2008/02/27/solving-puzzles-of-mitochondrial-variation-within-and-among-species/ About DNA barcoding Mon, 09 Jan 2012 14:28:05 +0000 hourly 1 http://wordpress.org/?v=3.2 By: James Stewart http://phe.rockefeller.edu/barcode/blog/2008/02/27/solving-puzzles-of-mitochondrial-variation-within-and-among-species/comment-page-1/#comment-51141 James Stewart Wed, 27 Feb 2008 20:11:33 +0000 http://phe.rockefeller.edu/barcode/blog/2008/02/27/solving-puzzles-of-mitochondrial-variation-within-and-among-species/#comment-51141 Thank-you for the interest in our work. The area has been producing some interesting results of late. Here are some other recent articles. Another germline selection experiment. Eric A. Shoubridge and Timothy Wai PERSPECTIVE: MEDICINE: Sidestepping Mutational Meltdown Science 2008 319, (5865) 914-915. Weiwei Fan, Katrina G. Waymire, Navneet Narula, Peng Li, Christophe Rocher, Pinar E. Coskun, Mani A. Vannan, Jagat Narula, Grant R. MacGregor, and Douglas C. Wallace A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations Science 2008 319, (5865) 958-962. Redefining the bottleneck... Cree LM, Samuels DC, de Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR, Dahl HH, Chinnery PF. "A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes." Nat Genet. 2008 40(2):249-54. Cao L, Shitara H, Horii T, Nagao Y, Imai H, Abe K, Hara T, Hayashi J, Yonekawa H. "The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells." Nat Genet. 2007 39(3):386-90. Thank-you for the interest in our work. The area has been producing some interesting results of late. Here are some other recent articles.

Another germline selection experiment.

Eric A. Shoubridge and Timothy Wai PERSPECTIVE: MEDICINE: Sidestepping Mutational Meltdown Science 2008 319, (5865) 914-915.

Weiwei Fan, Katrina G. Waymire, Navneet Narula, Peng Li, Christophe Rocher, Pinar E. Coskun, Mani A. Vannan, Jagat Narula, Grant R. MacGregor, and Douglas C. Wallace
A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations Science 2008 319, (5865) 958-962.

Redefining the bottleneck…

Cree LM, Samuels DC, de Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR, Dahl HH, Chinnery PF. “A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.” Nat Genet. 2008 40(2):249-54.

Cao L, Shitara H, Horii T, Nagao Y, Imai H, Abe K, Hara T, Hayashi J, Yonekawa H.
“The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.” Nat Genet. 2007 39(3):386-90.

]]> By: Mark Stoeckle http://phe.rockefeller.edu/barcode/blog/2008/02/27/solving-puzzles-of-mitochondrial-variation-within-and-among-species/comment-page-1/#comment-51133 Mark Stoeckle Wed, 27 Feb 2008 17:22:01 +0000 http://phe.rockefeller.edu/barcode/blog/2008/02/27/solving-puzzles-of-mitochondrial-variation-within-and-among-species/#comment-51133 This model suggests there might be selection at the level of the bottleneck itself. According to this idea, mitochondria and host are in competition, with many mitochondria trying to get into the egg, and the host acting as a gatekeeper, trying to let in just one or a few. Like a host-parasite interaction, this could be a continuous arms race that leads to rapid co-evolutionary change. This model suggests there might be selection at the level of the bottleneck itself. According to this idea, mitochondria and host are in competition, with many mitochondria trying to get into the egg, and the host acting as a gatekeeper, trying to let in just one or a few. Like a host-parasite interaction, this could be a continuous arms race that leads to rapid co-evolutionary change.

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